Alan H Fairlamb Selected Research

Trypanosomiasis

1/2019	Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis.
4/2010	N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
12/2009	Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.
11/2008	ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides.
9/2006	Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate.
2/2006	Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme.

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Alan H Fairlamb Research Topics

Disease

21	African Trypanosomiasis (Nagana) 01/2018 - 06/2003
13	Visceral Leishmaniasis (Kala Azar) 01/2021 - 03/2006
9	Leishmaniasis 01/2019 - 06/2003
6	Trypanosomiasis 01/2019 - 02/2006
6	Malaria 01/2019 - 10/2002
5	Infections 01/2021 - 11/2010
5	Chagas Disease (American Trypanosomiasis) 01/2020 - 06/2003
4	Neglected Diseases 01/2019 - 12/2007
2	Tuberculosis (Tuberculoses) 01/2021 - 10/2013
2	Parasitic Diseases (Parasitic Disease) 12/2013 - 04/2006
1	Bacterial Infections (Bacterial Infection) 01/2021
1	Plague (Bubonic Plague) 11/2019
1	Cryptosporidiosis 01/2019
1	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 01/2016
1	Neoplasms (Cancer) 02/2012
1	Communicable Diseases (Infectious Diseases) 02/2012
1	Cutaneous Leishmaniasis 11/2007

Drug/Important Bio-Agent (IBA)

29	Pharmaceutical PreparationsIBA 11/2019 - 06/2003
4	EnzymesIBA 11/2019 - 06/2003
4	glycylpeptide N-tetradecanoyltransferaseIBA 01/2016 - 04/2010
4	trypanothione reductaseIBA 10/2011 - 06/2003
3	NifurtimoxIBA 04/2016 - 07/2010
3	ArsenicIBA 03/2015 - 09/2011
3	Antimony Sodium Gluconate (Sodium, Stibogluconate)IBA 12/2013 - 09/2004
3	fexinidazoleIBA 10/2013 - 02/2012
2	Nitro CompoundsIBA 01/2019 - 11/2016
2	miltefosine (Impavido)IBA 01/2019 - 02/2012
2	OPC-67683IBA 11/2016 - 01/2016
2	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 01/2016 - 09/2006
2	Proteins (Proteins, Gene)FDA Link 01/2016 - 01/2015
2	NitroreductasesIBA 10/2013 - 02/2013
2	Eflornithine (Ornidyl)FDA Link 05/2013 - 07/2010
2	SpermidineIBA 05/2013 - 04/2006
2	HydroquinonesIBA 02/2012 - 03/2011
2	trypanothione synthetaseIBA 01/2012 - 12/2009
2	Glutathione (Reduced Glutathione)IBA 11/2007 - 02/2006
2	VaccinesIBA 03/2006 - 10/2002
2	Sulfhydryl Compounds (Thiols)IBA 01/2006 - 09/2004
1	benzothiopheneIBA 01/2021
1	Complement System Proteins (Complement)IBA 01/2021
1	Lysine-tRNA LigaseIBA 01/2019
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2019
1	Melarsoprol (Mel B)IBA 01/2018
1	Aldo-Keto ReductasesIBA 01/2018
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2018
1	Arsenicals (Arsenic Compounds)IBA 01/2018
1	benzonidazole (benznidazole)IBA 01/2018
1	GSK3186899IBA 01/2018
1	Phosphotransferases (Kinase)IBA 01/2018
1	Protein Kinases (Protein Kinase)IBA 11/2017
1	prolyl T RNA synthetaseIBA 01/2017
1	Thymidylate SynthaseIBA 01/2016
1	thymidylate synthase-dihydrofolate reductaseIBA 01/2016
1	SCYX 7158IBA 12/2015
1	Guanosine Triphosphate (GTP)IBA 01/2015
1	Messenger RNA (mRNA)IBA 01/2015
1	Peptide Elongation Factor 2 (EF-2)IBA 01/2015
1	DDD107498IBA 01/2015
1	SulfonamidesIBA 12/2014
1	pyrazoleIBA 12/2014
1	Drinking WaterIBA 12/2013
1	Meglumine FDA Link 12/2013
1	Meglumine AntimoniateIBA 12/2013
1	MetalloidsIBA 12/2013
1	AntimonyIBA 12/2013
1	pretomanidIBA 10/2013
1	ProdrugsIBA 10/2013
1	Antitubercular AgentsIBA 10/2013
1	PolyaminesIBA 05/2013
1	NitroimidazolesIBA 02/2013
1	PoisonsIBA 09/2011
1	Triclosan (pHisoHex)FDA Link 01/2011
1	Opioid Analgesics (Opioids)IBA 11/2010
1	pteridine reductaseIBA 07/2009
1	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 11/2008
1	tryparedoxinIBA 09/2008
1	Peroxidase (Myeloperoxidase)IBA 09/2008
1	PeroxidasesIBA 11/2007
1	PterinsIBA 09/2006
1	Folic Acid AntagonistsIBA 09/2006
1	AlkaloidsIBA 04/2006
1	lunarineIBA 04/2006
1	Oxidoreductases (Dehydrogenase)IBA 04/2006
1	LatexIBA 03/2006
1	AntigensIBA 03/2006
1	4-O-carboxymethylascochlorinIBA 03/2006
1	Oxidants (Oxidizing Agents)IBA 02/2006
1	trypanothioneIBA 02/2006
1	XenobioticsIBA 02/2006
1	Pyruvaldehyde (Methylglyoxal)IBA 02/2006
1	Lactoylglutathione LyaseIBA 08/2005

Therapy/Procedure

5	Therapeutics 01/2020 - 01/2006
3	Drug Therapy (Chemotherapy) 02/2013 - 11/2003
1	Oral Administration 01/2019